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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T11078 | Deschloroclozapine | Serotonin Transporter | |
Deschloroclozapine, a metabolite of Clozapine, is a highly potent muscarinic DREADDs agonist. Deschloroclozapine binds to DREADD receptor subtypes hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively. | |||
T1760 | TBPB | AChR | |
TBPB is an allosteric M1 mAChR agonist. | |||
T4981 | Anisotropine Methylbromide | Prostaglandin Receptor , AChR | |
Anisotropine Methylbromide is an anticholinergic agent and has been used for relief of gastrointestinal spasm and for the suppression of gastric acid secretion. | |||
T9419 | Fesoterodine | (R) Fesoterodine | AChR |
Fesoterodine ((R) Fesoterodine) is an orally active, competitive mAChR antagonist with pKi values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. It is used for the overactive bladder (OAB). | |||
T7555 | Piperidolate hydrochloride | AChR | |
Piperidolate hydrochloride is an antimuscarinic, could restrain the abnormal activity caused by acetylcholine. inhibits intestinal cramp induced by acetylcholine (rats and dogs). | |||
T23116 | Oxotremorine sesquifumarate | AChR | |
Oxotremorine sesquifumarate is a muscarinic agonist. | |||
T8304 | Anisodamine Hydrobromide | 6-Hydroxyhyoscyamine | Adrenergic Receptor , AChR |
Anisodamine Hydrobromide (6-Hydroxyhyoscyamine) is an anticholinergic and α1-adrenergic receptor antagonist used in the treatment of acute circulatory shock. | |||
T1281 | Tropicamide | Ro 1-7683 | AChR |
Tropicamide (Ro 1-7683) is a synthetic muscarinic antagonist with actions similar to atropine and with an anticholinergic property. Upon ocular administration, tropicamide binds to and blocks the muscarinic receptors in ... | |||
T11095L | DREADD agonist 21 | 5-HT Receptor , Adrenergic Receptor , AChR , Histamine Receptor | |
DREADD agonist 21 is a potent agonist of human muscarinic acetylcholine M3 receptors (EC50=1.7 nM). | |||
T15942 | MK-7622 | M1 receptor modulator | AChR |
MK-7622 (M1 receptor modulator) is a modulator of muscarinic M1 receptor positive allosteric. | |||
T9694 | Emraclidine | CVL-231 | AChR |
Emraclidine (CVL-231) is a muscarinic M4 receptor positive allosteric modulator and can be used in neurological diseases studies. | |||
T8196 | Arborine | Arborin | Others , AChR |
Arborine (Arborin) is a larval growth inhibitor from glycoslnis pentaphylla. | |||
T4979 | Procyclidine hydrochloride | (±)-Procyclidine hydrochlorid | NMDAR , iGluR |
Procyclidine hydrochloride ((±)-Procyclidine hydrochlorid) is a potent anticholinergic agent and also have NMDA antagonist properties. | |||
T9353 | OXOMEMAZINE | AChR , Histamine Receptor | |
Oxomemazine is a phenothiazine-based histamine H1-receptor blocker with pronounced antimuscarinic activity. Oxomemazine is a selective antagonist of mycotoxins M1 receptors, showing high (Ki=84 nM, M1 receptors) and low ... | |||
T6575 | LY2119620 | AChR | |
LY2119620 is a specific, and allosteric agonist of human M2 and M4 muscarinic acetylcholine receptors. | |||
T5655 | MAChR-IN-1 hydrochloride | AChR | |
mAChR-IN-1 hydrochloride is a potent muscarinic cholinergic receptor (mAChR) antagonist, with an IC50 of 17 Nm. | |||
T8219 | VU0238441 | AChR | |
VU0238441 is agonist of Muscarinic acetylcholine receptor M5 (human) with EC50 of 2.1μM. | |||
T13066 | TAK-071 | AChR | |
TAK-071 is a potent, novel and highly selective modulator of muscarinic acetylcholine receptor 1 (M1R) positive allosteric(EC50 : 520 nM). | |||
T17244 | VU0467154 | AChR | |
VU0467154 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor. The response to ACh with pEC50s of 7.75, 6.2, and 6 for a rat, human, and cynomolgus monkey M4 receptor, respectively. | |||
T1475 | Fesoterodine fumarate | Toviaz,SPM 907 | AChR |
Fesoterodine fumarate (Toviaz) is the fumarate salt form of fesoterodine, a competitive muscarinic receptor antagonist with muscle relaxant and urinary antispasmodic properties. Fesoterodine is rapidly hydrolyzed in vivo... |